The unidentified woman was pushing a baby stroller on Lexington Avenue and East 95th Street around 8:25 p.m. when a man wearing a black hooded sweatshirt came up from behind and shot her in the head, WABC reported.
An unknown person approached her and fired a single shot at close range, police said. The suspect fled immediately afterward on foot, traveling east along East 95th Street, according to the NYPD. He was last seen wearing a hooded sweatshirt and sweatpants, in all black.
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NYPD responded to the scene and encountered a female victim who was unconscious and unresponsive, with a gunshot wound to the head.
The woman was taken to Metropolitan Hospital, where she was pronounced dead at 9:20 p.m., police said.
Police said the baby was unharmed, WABC reported.
No arrests have been made and an investigation is ongoing, police said.